Immunology and surgery

Surge2Surgery is grounded in more than seven years of clinical, basic science, and translational research led by our team at Stanford University

PUBLICATIONS

SCIENCE TRANSLATIONAL MEDICINE

2014

CLINICAL RECOVERY FROM SURGERY CORRELATES WITH SINGLE-CELL IMMUNE SIGNATURES

Brice Gaudillière, Gabriela K. Fragiadakis, Robert V. Bruggner et al.

Science Translational Medicine, 2014

ANESTHESIOLOGY 

2015

PATIENT-SPECIFIC IMMUNE STATES BEFORE SURGERY

ARE STRONG CORRELATES

OF SURGICAL RECOVERY

Gabriela K Fragiadakis, Brice Gaudillière, Edward A Ganio et al.

Anesthesiology, 2015

JOURNAL OF IMMUNOLOGY 

2017

DEEP IMMUNE PROFILING OF AN ARGININE-ENRICHED NUTRITIONAL INTERVENTION IN PATIENTS UNDERGOING SURGERY

Nima Aghaeepour, Cindy Kin, Edward A. Ganio,  et al.

Journal of Immunology, 2017

NATURE COMMUNICATIONS

2020

PREFERENTIAL INHIBITION OF ADAPTIVE IMMUNE SYSTEM DYNAMICS BY GLUCOCORTICOIDS IN PATIENTS AFTER ACUTE SURGICAL  TRAUMA

Edward A. Ganio, Natalie Stanley, Viktoria Lindberg-Larsen, et al.

Nature Communications, 2020

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PROVISIONAL PATENT

2021

AN INTEGRATED SURGICAL RISK SCORE METHOD FOR THE PREDICTION OF POSTOPERATIVE OUTCOMES

Julien Hedou, Kristy Rumer, Nima Aghaeepour, Martin Angst, Brice Gaudilliere

Provisional patent, 2021

ONGOING CLINICAL TRIAL

Research validating our approach

PROSPECTIVE STUDY

We designed a prospective, monocentric, randomized, single-blinded, controlled trial aiming to recruit patients undergoing elective major surgery

OBJECTIVE

To assess the benefits of a personalized, health-optimization program combining one-on-one coaching, tailored to each patient's baseline, on patients' immune state prior to elective, major surgery under general anesthesia.

NUMBER OF PATIENTS TO BE INCLUDED

80 patients

STUDY DURATION

16 months, started October 1, 2020

CLINICALTRIAL.GOV 

Find the complete protocol #NCT04498208 here: clinicaltrial.gov

Médecin et patient

OUR SCIENTIFIC BOARD

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MARTIN ANGST, MD

Professor of Anesthesiology, Perioperative & Pain Medicine
Stanford University

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PATRICK NATAF, MD, PHD

Professor

of Cardiac Surgery
Université de Paris

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GARRY NOLAN, PHD

Professor of Microbiology and Immunology
Stanford University

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ROBERT TIBSHIRANI, PHD

Professor of Statistics and Biomedical Data Science
Stanford University

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STUART GOODMAN, MD, PHD

Professor of Orthopedic Surgery

Stanford University